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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RPS6KA4
All Species:
30.61
Human Site:
S504
Identified Species:
44.89
UniProt:
O75676
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75676
NP_001006945.1
772
85606
S504
K
K
R
H
F
S
E
S
E
A
S
Q
I
L
R
Chimpanzee
Pan troglodytes
XP_508900
901
98668
S633
K
K
R
H
F
S
E
S
E
A
S
Q
I
L
R
Rhesus Macaque
Macaca mulatta
XP_001114877
772
85557
S504
K
K
R
H
F
S
E
S
E
A
S
Q
I
L
R
Dog
Lupus familis
XP_854926
772
85603
S505
K
K
R
H
F
S
E
S
E
A
S
Q
I
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B9
773
85721
S504
K
K
R
L
F
S
E
S
E
A
S
Q
I
L
R
Rat
Rattus norvegicus
Q63531
735
82865
L475
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506738
716
80894
T436
K
K
K
H
F
S
E
T
E
A
S
S
I
M
R
Chicken
Gallus gallus
Q5F3L1
789
89022
T509
K
K
Q
H
F
S
E
T
E
A
S
H
I
M
R
Frog
Xenopus laevis
P10665
733
82620
L473
Q
H
P
N
I
I
A
L
K
D
V
Y
K
E
G
Zebra Danio
Brachydanio rerio
Q6PFQ0
740
83378
G484
L
K
D
V
Y
D
E
G
R
F
V
Y
L
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3I5
1207
137026
D714
A
S
I
R
M
D
E
D
S
C
R
E
I
F
L
Honey Bee
Apis mellifera
XP_395099
910
102507
Q539
R
P
R
P
F
S
D
Q
Q
A
S
R
I
M
R
Nematode Worm
Caenorhab. elegans
Q18846
772
87050
S475
K
L
E
R
F
T
E
S
E
A
A
D
I
M
R
Sea Urchin
Strong. purpuratus
XP_786494
918
102561
L476
K
K
K
H
F
D
E
L
E
A
S
M
I
M
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q39030
471
53019
Y214
F
Q
T
K
Y
R
L
Y
L
V
L
D
F
I
N
Baker's Yeast
Sacchar. cerevisiae
P18961
677
76646
L421
P
E
K
L
Y
L
V
L
A
F
I
N
G
G
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.4
98.6
96.7
N.A.
95.8
41.3
N.A.
56
64
41
41.9
N.A.
27
45.1
48.1
48.2
Protein Similarity:
100
85.6
98.9
98
N.A.
96.7
60.6
N.A.
71.6
78.4
59
60.3
N.A.
38.9
60.1
64.3
61.8
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
73.3
73.3
0
13.3
N.A.
13.3
46.6
53.3
66.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
20
N.A.
93.3
93.3
20
33.3
N.A.
20
80
73.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.6
37.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
7
0
7
63
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
19
7
7
0
13
0
13
7
7
0
% D
% Glu:
0
7
7
0
0
0
69
0
57
0
0
7
0
7
7
% E
% Phe:
7
0
0
0
63
0
0
0
0
13
0
0
7
7
0
% F
% Gly:
0
0
0
0
0
0
0
7
0
0
0
0
7
7
7
% G
% His:
0
13
0
44
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
0
7
0
13
13
0
0
0
0
7
0
69
7
0
% I
% Lys:
57
57
19
7
0
0
0
0
13
0
0
0
7
0
0
% K
% Leu:
7
7
0
13
0
7
7
25
7
0
7
0
7
32
7
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
7
0
32
0
% M
% Asn:
0
0
0
13
0
0
0
0
0
0
0
7
0
0
7
% N
% Pro:
7
7
13
7
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
13
7
7
0
0
0
0
7
7
0
0
32
0
0
0
% Q
% Arg:
7
0
38
13
0
7
0
0
7
0
7
7
0
0
63
% R
% Ser:
0
7
0
0
0
50
0
38
7
0
57
7
0
0
7
% S
% Thr:
0
0
7
0
0
7
7
13
0
0
0
0
0
0
7
% T
% Val:
0
0
0
7
0
0
7
0
0
7
19
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
19
0
0
7
0
0
0
19
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _